Medications
Salbutamol
Beta-2 agonist bronchodilator for bronchospasm and hyperkalemia
Last updated: 2026-04-12Original source from BCEHS
Indications
Authorized
- Bronchospasm
Contraindications
- Known hypersensitivity to salbutamol
Adult Dosages
Authorized
Bronchospasm
- 5 mg nebulized; repeat doses back to back as necessary
- 4 x 100 mcg via metered dose inhaler with spacer; repeat as required
- In patients without influenza-like illness (ILI), nebules are preferred. In patients with ILI or other infectious respiratory conditions, MDI and spacer use is strongly recommended.
Pediatric Considerations
Authorized - bronchospasm
Via nebulizer
- Age <1 year: 2.5 mg
- Age ≥1 year: 5 mg
Via metered dose inhaler
- <10 kg: not indicated
- 10-20 kg: 5 x 100 mcg per course; may repeat up to 3 times
- >20 kg: 10 x 100 mcg per course; may repeat up to 3 times
Adverse Effects
- Restlessness, weakness, vertigo, apprehensiveness
- Nausea and vomiting
- Tachycardia or other dysrhythmias
- Paradoxical worsening of respiratory distress
- Cough
- Pulmonary edema
- Sweating, pallor, flushing
- Tremors
Additional Information
Mechanism of Action
Salbutamol is a selective beta-2 adrenergic agonist that produces bronchodilation and some degree of vasodilation. Some beta-1 effects can be seen, particularly at higher doses.
Pharmacokinetics
| Route | Onset | Peak | Duration |
|---|---|---|---|
| Inhaled | 5-15 minutes | 60-90 minutes | 3-6 hours |
Overdose
Discontinue administration if signs of toxicity develop: heart rate >150/minute (>200/minute in pediatrics); severe tremors; ventricular arrhythmias.