Indications

Contraindications

• Known hypersensitivity to ibuprofen or other anti-inflammatories including aspirin
• Known or suspected renal dysfunction (GFR or Creatinine Clearance less than 30 mL/min or patient identifies as having kidney dysfunction)
• Concern for severe active bleeding (trauma, intracranial hemorrhage, GI bleeding)
• Pregnancy
• Use of anticoagulant (eg. apixaban, rivaroxaban, warfarin, edoxaban, dabigatran)

Cautions

• Severe volume depletion/dehydration
• Active cardiac emergency (myocardial infarction)
• Anti-inflammatory within the last 6-12 hours (eg. ibuprofen, celecoxib, naproxen)

Adult Dosages

Pediatric Considerations

Adverse Effects

• The most common adverse reactions involve gastrointestinal upset, ranging from abdominal discomfort to gastric ulceration, bleeding, and perforation
• These events are unlikely following a single, out-of-hospital dose of ibuprofen, but care should be exercised in patients with a recent history of NSAID use

Additional Information

Mechanism of Action

Inhibits prostaglandin synthesis, reducing pain, inflammation, and pyrexia.

Pharmacokinetics

Overdose

The most common symptoms of NSAID overdose are gastrointestinal irritation and CNS depression. Care is primarily supportive.

Warnings and Precautions

Alternative treatment options should be considered in patients with a history of gastrointestinal, renal, or significant cardiovascular disease: ibuprofen, and all NSAIDs, have the potential to cause significant adverse reactions. The risk appears to increase with dose, duration of therapy, and underlying risk factors.

Drug Interactions

As a class of medications, NSAIDs may raise blood pressure, limiting the effectiveness of antihypertensives.